Wednesday, April 5, 2023

SGO Annual Mtg 2023: Miscellaneous topics

This post completes my coverage of the 2023 SGO Annual Meeting. Below are some tweets on  miscellaneous topics from treatments to testing.

 Cryocompression

Prevention of neuropathy in gyn cancer patients. 

 Immune Biomarkers in Locally Advanced Cervical Cancer 

Combo of durvalumab concurrent with radiation produce more tumor-associated T-cells clones. 

Palliative Care  

Higher value and less aggressive care at end of life with early palliative care.

Palliative care referral was impacted by diagnosis and insurance coverage. 

Breast MRI 

Denials in women with hereditary BRCA1/2 mutations with gyn cancer diagnosis.

Funding gaps  

Significant gaps in funding for gyn cancers compared to other cancer types

Obesity  

Japanese study showed obese women have higher risk of uterine cancer

HPV vaccination

Intervention helps uptake of HPV in clinic 

 Tremelimumab, durvalumab, and radiotherapy

Patients with cervical or vaginal cancers had good overall response rates if high in PDL1

In June I will report on  research of interest presented at the ASCO annual meeting which I will attend virtually. 

Dee

Every Day is a Blessing!

Tuesday, April 4, 2023

SGO Annual Mtg 2023 : Disparities/ Equity Research

In this post I will focus on sharing Tweets and information from the Diversity, Equity presentations I attended at the 2023 SGO Annual Meeting. There were a number of important studies presented to better understand equity issues for those diagnosed with a gynecologic cancer. 

Two studies focused on Asian / Pacific Islanders 

Do we need to separate out non-hispanic Pacific Islanders from Asians? 

Food deserts associated with worse survival outcomes.

 Cervical Cancer 

 

 

 

Clinical Trials - Comorbidity exclusions

Geographic disparities in access to gynecologic oncologists

 Health Literacy 

Low income and racial/ ethnic minorities had lower rates of health literacy which impacts health outcomes  


Additional information may be found at  https://www.healio.com/news/hematology-oncology/20230329/1-in-4-patients-at-gynecologic-oncology-clinic-lack-adequate-cancer-health-literacy

 

Caring for transgender patients

 Please visit Welcoming Spaces at https://www.sgo.org/welcomingspaces/ for more information. 



Tomorrow's post will highlight some other sessions of interest from palliative care, to compression therapy to  biomarkers to funding.  See you tomorrow!


Dee
Every Day is a Blessing! 

Monday, April 3, 2023

SGO Annual Mtg 2023 Highlights : Ovarian Cancer

I've gathered together some interesting Tweets about ovarian cancer research studies from the SGO 2023 Annual Meeting.

Botensilimab An Fc-engineered recombinant human immunoglobulin (Ig) G1 monoclonal antibody and Balstilimab a PD-1 inhibitor 

Additional information  https://www.cancernetwork.com/view/botensilimab-plus-balstilimab-yields-enduring-responses-in-r-r-ovarian-cancer

 

SOLAR Trial olaparib (Lynparza) with selumetinib (Koselugo) in patients with RAS-mutant gynecologic malignancies

Find additional information at https://www.onclive.com/view/dr-westin-on-outcomes-of-the-solar-trial-in-ras-mutant-gynecological-malignances


SOLO 1 trial results - 7 year overall survival reported

Additional information may be found at https://www.onclive.com/view/dr-mathews-on-maintenance-olaparib-in-ovarian-cancer

 

NOVA trial Recurrent ovarian cancer - Niraparib (Zejula) did not produce a statistically significant overall survival (OS) benefit compared with placebo.  

 

Minimally invasive surgery vs open surgery

 

Neoadjuvant olaparib - improved surgical outcomes 

 For additional information see https://www.onclive.com/view/neoadjuvant-olaparib-proves-feasible-aids-optimal-resection-in-brca-mutant-ovarian-cancer

mirvetuximab soravtansine-gynx (Elahere)

Steroid eye drops followed by lubricating eye drops and regular visits to an ophthalmologist should be scheduled . For more information see https://www.onclive.com/view/dr-matulonis-on-the-management-of-mirvetuximab-soravtansine-related-toxicities-in-fr-ovarian-cancer

venous thromboembolism (VTE)

 

For additional information see https://www.medpagetoday.com/meetingcoverage/sgo/103793

If you would like to share additional ovarian cancer studies presented at SGO 2023 please mention in the comment section below. Thanks.

Stop by tomorrow to read Tweets that highlighted studies on equity, diversity at the meeting.

 

Dee
Every Day is a Blessing! 

 

Sunday, April 2, 2023

SGO Annual Mtg 2023 Highlights: Endometrial Cancer

The Late Breaking Abstracts session at the SGO Annual meeting included two important endometrial cancer studies using immune checkpoint inhibitors.

Dr Eskander presented Pembrolizumab versus Placebo in Addition to Carboplatin and Paclitaxel for Measurable Stage 3 or 4a, Stage 4b or recurrent Endometrial Cancer : Phase 3 NRG GYO18 Study (Keynote 868)

Pembrolizumab is an immune checkpoint inhibitor that binds to the protein PD-1.  Endometrial cancer patients who were stage III, IVa , IVB or recurrent endometrial cancer enrolled in the trial. They were given carboplatin / paclitaxel ( Standard of care) with pembrolizumab, a PD1 inhibitor or placebo followed by maintenance with pembrolizumab. Patients were separated into two cohorts according to whether they had mismatch repair–deficient (dMMR) or mismatch repair–proficient (pMMR) disease. The interim efficacy analysis showed in the pMMR cohort, median progression-free survival was 13.1 months with pembrolizumab and 8.7 months with placebo. 

The study was released minutes after the presentation Sunday afternoon in the NEJM.  https://www.nejm.org/doi/full/10.1056/NEJMoa2302312  Additional information may be found here.


Page 1 of "Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer" by Eskander et al.

Dr Mirza presented Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer. (Ruby trial)

Dostarlimab, an immune checkpoint inhibitor to anti-programmed cell death receptor-1 (PD-1) was used in this Phase 3 trial. Women  with stage III, IV or recurrent endometrial cancer were give dostarlimab with carboplatin/ paclitaxel and then maintenance dostarlimab every 6 weeks for up to 3 years. In the dMMR–MSI-H ( mismatch repair–deficient, microsatellite instability–high) population, estimated progression-free survival at 24 months was 61.4%  versus 15.7% in the placebo group. Overall survival at 24 months was 71.3% with dostarlimab and 56.0% with placebo.   

This study was also published online in the NEJM shortly after the presentation. nej.md/40lFbBN
Additional information may be read here

Page 1 of "Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer" by Mirza et al.

This tweet sums up the two studies

Comments that I heard from various gynecologic oncologists after the session was that these two studies will impact endometrial cancer patient care in the near future.

 More SGO news to come!

 

Dee

Every day is a blessing!