I knew Lynch syndrome associated with colorectal cancer but I wasn't sure how strong a connection there was between Lynch Syndrome and ovarian cancer.
"Lynch Syndrome is also known as hereditary non-polyposis colorectal cancer (HNPCC), is a type of inherited cancer of the digestive tract. Lynch syndrome increases a woman's risk of ovarian and uterine cancer. It is caused by mutations in several different genes. Lynch syndrome also increases the risk of colorectal cancer, as well as cancers of thestomach, small intestine, liver, bile duct, urinary tract, the brain and central nervous system, and possibly breast cancer. http://www.cancer.net/all-about-cancer/genetics/genetics-ovarian-cancer
Mutations in the MLH1 or MSH2, MSH6 or PMS2 or EPCAM genes are associated with Lynch Syndrome. Families with Lynch syndrome have two or more members who have colorectal, endometrial , ovarian or other cancer.
For more information about the test for Lynch Syndrome see this page.
Here is some interesting research on the Lynch Syndrome Ovarian Cancer link.
* Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors.
* The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer.
Every Day is a Blessing!