Tuesday, September 18, 2012

OC awareness month #18 - Lynch Syndrome

While at the ASCO meeting in June I spent some time talking to the Myriad representatives. Myriad is the company that does the genetic testing for gene mutations, deletions and additions. I asked if the test used today is any different from the one they used to test my blood  6 years ago. There response was that they would test for LYNCH SYNDROME.

I knew Lynch syndrome associated with colorectal cancer but I wasn't sure how strong a connection there was between Lynch Syndrome and  ovarian cancer.

"Lynch Syndrome is also known as hereditary non-polyposis colorectal cancer (HNPCC), is a type of inherited cancer of the digestive tract. Lynch syndrome increases a woman's risk of ovarian and uterine cancer. It is caused by mutations in several different genes. Lynch syndrome also increases the risk of colorectal cancer, as well as cancers of thestomachsmall intestineliverbile ducturinary tract, the brain and central nervous system, and possibly breast cancerhttp://www.cancer.net/all-about-cancer/genetics/genetics-ovarian-cancer
Mutations in the MLH1 or MSH2, MSH6 or PMS2 or EPCAM genes  are associated with Lynch Syndrome. Families with Lynch syndrome have two or more members who have colorectal, endometrial , ovarian or other cancer.

For more information about the test for Lynch Syndrome see this page.

Here is some interesting research on the Lynch Syndrome Ovarian Cancer link.

Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors.

The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer.

Every Day is a Blessing!

1 comment:

Scoobydoobeach said...

Thank you for this information. I have a family history of uterine cancer so it may be useful to know if there is a hereditary component to my cancer. The odds are against it but my daughter, granddaughter and nieces should know.