Friday, September 21, 2012

OC Awareness #21 - HIgh Grade Serous subtypes

The article

Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome

appeared in a recent issue of Clinical Cancer Research. Researchers at Dana Farber using a process called single nucleotide polymorphism (SNP) arrays were able to examine single units in the genetic code of tumor cells of high grade serous ovarian cancer ( HGSOC) . HGSOC cells have many genetic abnormalities including missing or extra chromosomes and  On examination the HGSOC fell into three groups based on abnormalities or loss of heterozygosity ( LOH). (Heterozygosity is having dissimilar pairs of genes.) One group had a high level of LOH and a loss of chromosome 13. The researchers found that patients in this group were slow to develop resistance to chemotherapy drugs and also were found to have the longest progression free survival.

A good review of the study can be found at

Every Day is a Blessing!

No comments: