Wayne State University researchers found freezing ovarian cancer tumors improved survival rates in women with late stage disease who present with a small number of tumors. Twenty-one women were in the study ("Cryoablation of Metastatic Ovarian Cancer for Local Tumor Control: Improved Survival and Estimated Cost-Effectiveness, ) using cryoablation.
OC Progression and Dendritic Cells
Using mouse models Wistar Cancer Center researchers have found that a women's own dendritic cells may aid in the progression of malignant ovarian cancer cells into metastatic disease. The dendritic cells alert the immune system to threats but also suppress other anti-tumor cells from working properly. Researchers are already working on reprogramming RNA to restore these dendritic cells to their tumor fighting role.
Journal Article- http://jem.rupress.org/content/early/2012/02/15/jem.20111413
News Article - http://www.news-medical.net/news/20120220/Targeting-patients-own-dendritic-cells-may-help-restore-the-immune-system.aspx
Thrombocytosis ( high platelet levels) and high levels of interleikin -6 was associated with advanced disease and shortened survival . The study analyzed 619 patients with epithelial ovarian cancerand then looked at human samples and mouse models to study the mechanism of the thromobcytosis.
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