Glycobiology is the study of glycoproteins. Glycoproteins are molecules made up of carbohydrates and proteins. The surface of epithelial cells are protected by carbohydrates. When a cell becomes cancerous the surface carbohydrates are altered and may contribute to cell growth and metastasis. Dr Fukuda and her postdocs worked with a monoclonal antibody (HMOCC-1) that attaches itself to the surface of malignant Ovarian Cancer cells. They developed a biochemical method to determine which modified carbohydrate the antibody attached itself to. The complete research article was published in the Journal of Biological Chemistry . Click here for a link to the article.
The more we understand the structure of ovarian cancer cells the better we can develop treatments.
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