Below is a list of drugs you may be offered:
Chemotherapy Drugs for Recurrence platinum sensitive:
- Cisplatin or carboplatin + paclitaxel
- Carboplatin + gemcitabine
- Carboplatin + pegylated liposomal doxorubicin
- Carboplatin + epirubicin
- Cisplatin + doxorubicin + cyclophosphamide ( recurrence 12+yrs)
Carboplatin and Taxol are considered the standard for first time platinum sensitive recurrence
Chemotherapy Drugs for Recurrence Platinum Resistant
- Paclitaxel
- Topetecan
- Gemcitabine
- Pegylated liposomal doxorubicin
- Pegylated liposomal doxorubicin + trabectedina
- Etoposide
- Hexamethylmelamine (Altretamine)
- Irinotecan
- Oxaliplatin
- Vinorelbine
- Fluorouracil and capecitabine
- Tamoxifen
- Pemetrexed
- Bevacizumab
- The U.S. Food and Drug Administration has approved the use of bevacizumab ( Avastin) in combination with pegylated liposomal doxorubicin, paclitaxel, or topotecan. Two trials OCEANS and AURELIA showed the improvement in PFS ( progression free survival).
- Olaparib (PARP inhibitor)- maintenance (9/12/17 FDA Approval) / after 3 or more chemotherapy treatments and a BRCA mutation (2014 FDA approval)
- Rucaparib ( BRCA mutations, 2 or more chemotherapy treatments, 2016)
- Niraparib(Maintenance therapy BRCA mutation not required)
For additional information about each of these treatments and evidence for their use please see
https://www.cancer.gov/types/ovarian/hp/ovarian-epithelial-treatment-pdq#link/_789
https://www.cancer.gov/news-events/cancer-currents-blog/2017/fda-olaparib-ovarian-cancer-maintenance?cid=eb_govdel
or the NCCN guideline page
https://www.nccn.org/patients/guidelines/ovarian/index.html#63/z
Dee
Every Day is a Blessing !
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