OVA1 test by Vermillion is a blood test that evaluates whether an ovarian mass is cancerous prior to surgery. OVA1 is FDA approved for that purpose. CA-125 is one of the five biomarkers used in the OVA1 test. The other markers are Beta-2 microglobulin, apoliprprotein A-1, prealbumin, and transferrin. The test results are evaluated using a proprietary algorithm to produce a result. The resulting number is between 0-10.
Recently a study of OVA1 was published in the Journal Gynecologic Oncology .
The study included 494 patients from multiple centers. Blood samples (taken prior to surgery) and physicians risk assessments were correlated with surgical pathology reports.
Ova1 correctly predicted ovarian cancer 91% of the cases of early stage cancer vs 65.7% using CA-125 alone. The OVA1 test was also better at predicting the absence of disease with a negative predicitive vale of 98.1%.
The study concluded that the OVA1 - 5 marker test "demonstrated higher sensitivity and negative predictive value for ovarian malignancy compared to clinical impression and CA125-II in an intended-use population of non-gynecologic oncology practices."
It is a very interesting study.
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