News about Anemia drugs- JAMA

When cancer patients experience chemo induced anemia (low hemoglobin levels) they sometimes are prescribed erythropoiesis stimulating agents (ESAs). Two commonly used drugs are called Aranesp from Amgen and Procrit from Johnson & Johnson. Yesterday, the NY Times published a column describing the results of a study printed in JAMA of clinical trials that used those drugs. The study concluded that cancer patients given the ESA's were shown to have decreased survival rates and increased incidence of blood clots.

I took Procrit a few times during my treatment so this article really makes me think about what I would do faced with postponing chemo due to low hemoglobin/red cells. I guess the FDA will have to consider if the risk of taking the drug outweighs what would occur if patients treatments were postponed due to low hemoglobin/ red count.

My Good News

I got word this morning that my CA-125 is down again- back to where it was in November.
Good News- indeed.

LiveStrong!
Dee

The End of an Era

This is the view of the Belmar beach at the end of 9th Avenue taken yesterday. That was the day we finished cleaning out Grandma's apartment. It is good that Grandma is in a safe, warm place with people watching out for her. It is sad to leave behind a place that was the Jersey "home" for over 30 years. Memories.....


Dee
LiveStrong!

Talc and Ovarian Cancer

"Perineal talc and ovarian cancer : a clinical review"

This article was written by Penn State College of Medicine professors. Over the past 25 years a number of studies were done to see if there was a link between talc, a silicate compound, and Ovarian Cancer. (I can remember when I was young putting lots of talc on a big soft pink powder puff and using it after a nice warm bath.) Anyway, a review of all the studies concluded "Talc is not genotoxic." and "These data collectively do not indicate that cosmetic talc causes ovarian cancer".
Since asbestos another silicate compound is connected to other types of cancer it was thought that use of talc in the 1950's could cause OC.
(European Journal of Cancer Prevention)

So one more thing we can cross of the list list as contributing to OC.

Thanks to the ACOR listserv for info on this study.
Dee
LiveStrong!

Finally Significant Snowfall

Just reporting the first significant snowfall for NJ today.

FDA Approves Avastin for Breast Cancer

Avastin, produced by Genentech, has been approved as a breast cancer treatment by the FDA. It was previously approved for lung and colon/ rectal cancer treatment. The chemical name for Avastin is bevacizumab. It is known as an angiogenesis inhibitor. Angiogenesis is a process where cancer cells produce a chemical which causes surrounding cells to produce new blood vessels that feed the cancer tissue. The studies done by Genentech show a slowing down /stopping of breast cancer tumor growth.Avastin is used with other chemotherapy drugs like 5-FU or carboplatin. There are some side effects - bowel perforations is one.

So why am I writing about Avastin? I have read about clinical trials of Avastin in Ovarian Cancer treatment. It seems that ovarian cancer cells may produce a VEGF -Vascular Endothelial Growth Factor. This factor causes angiogenesis and Avastin can counteract the VEGF. I know that is a simple version of what happens so if you want to check Avastin out in greater detail see:
Avastin Page
or
Marketwatch Page

Remember to LiveStrong!
Dee

Meeting Another LAF Supporter

This past weekend was spent at Woodloch Pines resort in Hawley, Pennsylvania. We have been going for a number of years with my cousins and have made friends with the staff. One staff member, Kathy, who knew of my ovarian cancer diagnosis told me to speak to the son of the owner, Bob Kiesendahl who was also a cancer survivor. On Sunday night before dinner I ran into Bob and we had a great talk. Turns out that Bob, a leukemia survivor of 8 years, was one of the LiveStrong Challenge Survivorship Award winners in 2006. He has raised over $250,000 for the Lance Armstrong Foundation. He also walked in the LiveStrong Challenge last year in Philly as I did. So we had a lot in common. We talked about how to go about raising funds for LAF and for our own cancer groups( his- Leukemia research and mine -Kaleidscope of Hope/ovarian cancer research). I bought chances in his BK Hope Cures raffle for a Harley Davidson. ( I will admit I am not sure what I would do if I win but it is a neat looking motorcycle.Maybe I can have it painted Teal.)I suggested that he and his mom Patty apply for the LiveStrong Summit this July in Ohio.I hope he does apply. This morning I received an e-mail from him and he will donate to Kaleidoscope. That is awesome. Thanks Bob! The more I meet people involved with the LAF , both survivors and caregivers, the more I feel we can be successful in our quest to find a cure for cancer.

Thanks to the Kiesendahl family for such a fun weekend and their support of cancer research. Happy 50th Anniversary Woodloch!

LiveStrong!
Dee