Showing posts with label risk. Show all posts
Showing posts with label risk. Show all posts

Tuesday, September 17, 2019

You Need to Know That...

An estimated 22,530 women will be diagnosed in the U. S. in 2019 
An estimated 13,980 women will die from the disease in 2019. 

There is no screening test for ovarian cancer.

There are symptoms:
Bloating, 
Feeling Full quickly, 
Frequent Urination, 
Abdominal/ Pelvic Pain, 
Fatigue

A women's risk of ovarian cancer in the U.S. is 1 in 7. 

The risks to develop ovarian cancer are :
Middle age or older ( half of the women diagnosed are over 63 yrs.)
BRCA mutation or Lynch Syndrome
Eastern European or Ashkenazi Jewish 
Have endometriosis
Never gave birth



Sources: CDC, American Cancer Society , OCRA

I hope you will consider sharing this information and donating to support ovarian cancer research. Thanks! 

Dee
Every day is a Blessing!

Thursday, February 27, 2014

Research News : Aspirin and Oophorectomies

ASPIRIN

Feb 6,2014 Journal of the National Cancer Institute

Chronic inflammation has been shown to increase the risk for cancer.Aspirin is known to possess  anti-inflammatory properties. Using data from 12 large epidemiological studies (8000 women with ovarian cancer and 12,000 without the disease) researchers at the NIH studied whether aspirin, non-aspirin NSAIDs (non-steroidal anti-inflammatory drugs) or acetaminophen had a lower risk of ovarian cancer.


Conclusion:  Daily use of low-dose aspirin was found to reduce the risk of ovarian cancer by 20-34% depending on the dose and frequency. The same low dose aspirin regime has show Cardiovascular  benefits.


My Take: Further prospective randomized studies are needed to verify this research.
There are risks to taking aspirin such as gastrointestinal bleeding but this may be a readily available low cost was to reduce a women's risk for ovarian cancer. .


OOPHORECTOMY 
Feb 24 Journal of Clinical Oncology

This study included over 5000 women with BRCA1 & 2  mutations who had their ovaries removed. The goal of the research was to estimate the reduction in the risk of developing ovarian, fallopian and peritoneal cancers by the age the women had their ovaries removed.The study also looked at the impact the surgery had on the women's mortality. 

Conclusion: Preventative oophorectomy in women with BRCA1 mutations reduces the risk of ovarian cancer by 80%. The study also found a 77% reduction in deaths by any cause by the age of 70 when women had the surgery. 

Recommendation: Women with BRCA1 mutation should  have their ovaries removed by age 35.  Waiting to a later age for the surgery increases the risk of being diagnosed with ovarian cancer. 

My Take: This study verified the importance of ovary removal at age 35 for women who carry the  BRCA1. Having to deal with menopause at an early age is not easy but women who are BRCA1 should discuss this surgery with their doctors . 


Notes:  Risk is the chance a person has of developing cancer over their lifetime. The risk of a woman developing ovarian cancer is 1.37 or 1 in 73 women. Data from ACS.


Dee
Every Day is a Blessing!

Saturday, February 2, 2013

Breastfeeding & Ovarian Cancer

Earlier this week I read the online article "Breastfeeding reduces ovarian cancer risk by 91%". I had breastfeed my daughter so I was interested in more details about the study. So I searched for the actual breastfeeding study in the American Journal of Clinical Nutrition to learn more. Although I could not read the entire article I could read the abstract.

Just reading the title  Ovarian Cancer risk is reduced by prolonged lactation :a case controlled study in southern china hinted that the study might hold some surprises. I had wrongly assumed the study was done in Australia since the article I read reported the researchers were from Australia. There was no mention in the article that the study subjects were from  Guangzhou, Gunagdong Province in China.  Between August 2006 and July 2008  women were given a questionnaire and asked to recall how many months they breastfeed (lactated ) and how many children they breastfeed. The questionnaires were given to 493 women with ovarian cancer and 473 women in the control arm.  The mean age of the women was 59.

The Australian researchers found an  inverse relationship between breastfeeding and ovarian cancer risk and an inverse relationship between the number of children breastfeed and ovarian cancer risk. In other words the longer you breast feed the lower your ovarian cancer risk and the more children you breastfeed the lower your ovarian cancer risk. The researchers concluded "Prolonged lactation is associated with a lower risk of ovarian cancer in parous Chinese women."( Parous women are child bearing women.)  So the study's conclusion related to Chinese women, not Autralian, American or European women.

This study was a retrospective study. In these type of studies researchers ask participants to recall if they did or used something ( breastfeed, exercise, drink coffee, use a drug)  to determine if it was a factor in developing a disease or condition later in life. If you asked me today in 2013 how long I breastfeed my daughter back in 1982  I would not be able to give you an exact answer. Was it 6 months?  9 months? I don't think it was more than 12 months but I am not sure. So in this type of study patient recall can impact the results.

This study is interesting. But if we repeat the study in the US would we get the same results? The original article I read did not mention other studies to support the results of the Australian study but did note the benefit of  breastfeeding to lower their risk of ovarian cancer.

Well, I did some research and back in 2007 the study "Breastfeeding and risk of ovarian cancer in two prospective cohorts."was published.  The results are part of the Nurses Health Study  and was a prospective study. A prospective study starts out with a healthy population with certain characteristics ( like having breastfeed) and the subjects are followed over time to see if a particular disease develops. This study concluded that there was no significant reduction in risk of ovarian cancer  in women who ever breastfeed or  never breastfeed.  But women who breastfeed 18 months or longer did show a significant reduction in risk for epithelial ovarian cancer.The average length of breastfeeding in this study was 9 months.

The conclusion of both studies is about increased risk of developing the disease. This Women's Cancer Network page does a nice job of explaining ovarian cancer risk.  The average woman's risk of developing ovarian cancer is 1 in 70.

I enjoy reading articles about cancer research studies and the related journal abstracts but sometimes find it frustrating that crucial details about the studies are often missing from media accounts.

Dee
Every Day is a Blessing !






Saturday, September 1, 2012

OC Awareness Month #1- Every Woman...

Today,  September 1st begins National Ovarian Cancer Awareness Month.

Every day on this Blog I will post information about ovarian cancer - statistics, risk factors, symptoms, treatments, etc.

#1 Every woman is at risk for ovarian cancer.

Sure different cancers can be found in men and women even breast cancer but it is the gynecologic cancers like ovarian ( uterine, endometrial, vulvar, cervical) that are only found in women. You can be young or old or middle age. You can be caucasian, african american, hispanic, asian. You can be born in the US, Canada, Europe , or Asia. But if you are a woman and you have ovaries or fallopian tubes ( which is being studied as the origin of ovarian cancer) you may develop ovarian cancer.


Dee
Every Day is a Blessing!