Showing posts with label #ASCO24. Show all posts
Showing posts with label #ASCO24. Show all posts

Tuesday, June 11, 2024

An Oncology Equity Summit and #ASCO24 Connections

On Monday June 3, 2024,  I had the opportunity to attend the Pfizer Oncology Health Care Equity Summit: Models for Collaboration and Community Action by Conquer Cancer's EveryGrant®. 

After being welcomed by Dr Katherine Reeder-Hayes, we heard from Dr Aida Habtezion, Chief Medical Officer of Pfizer. After reviewing the representation by race and ethnicity in clinical trials in the US, Dr Habtezion highlighted Pfizers committment to health equity in oncology. 


 

Next, a panel of presenters including advocate Sharon Rivera-Sanchez, shared their research and experience reaching underrepresented patients. 

Brian Rivers, PhD, MPH (Morehouse School of Medicine) spoke on the Deep South Community Health Advocates Network . The Network recruits and trains lay advocates/navigators as community health workers to disseminate cancer information on risk reduction, screening, survivorship and clinical trial participation. He also spoke on a project to improve access to primary care and promote education and preventive screenings for prostate cancer among rural African American men.

Shoshana Rosenberg, ScD, MPH (Weill Cornell Medical College) spoke on the unmet psychosocial needs among adults with metastatic breast cancer in New York City. She described the intervention RAISE,which uses an employment screening tool to assist  with the employment challenges experienced by metastatic  breast cancer patients treated at NYP-Weill Cornell Medicine (Manhattan) and Brooklyn Methodist Hospital. 

Kamran Ansari, MS Pfizer Oncology division spoke on Pfizer's approach to clinical trial diversity

Sharon Rivera-Sanchez, patient advocate and founder of Trials of Color spoke on the barriers to participation in clinical trials such as logistic and financial barriers, lack of awareness of trials, eligibility criteria, mistrust and the complexity of clinical trial platforms. Solutions include education, building relationships, simplifying enrollment, inclusive eligibility, and child care support. Her final remark needs highlighting!

Kenneth W. Merrell, MD, Medical Director Global Bridges, shared  the mission of Global Bridges to mobilize a global network of healthcare professionals and organizations dedicated to advancing effective diagnosis and treatment through medical education. The progam has training 50,000 Health Care Providers in 85 countries. They have provided 17 grants in oncology in the 2024-2026 cycle in Africa. 

Yanin Chavarri Guerra, MD, MSc Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubriran , Mexico spoke on the social determinants of health and disparities in cancer care for patients with metastatic breast cancer in Mexico. Patients were recruited from 3 hospitals. The barriers related to social determinants of health in patients with metastatic breast cancer may be addressed by system-level interventions.

Salvatore Alesci, MD, PhD, National Minority Quality Forum (NMQF) shared the NMQF vision to achieve a just and fair American health system that insures equitable access to optimal care. 

Andrew E. Chapman, DO, FACP, FCPP Director of the Sidney Kimmel Cancer Center at Jefferson concluded the panel discussion . He discussed how the ACES model ( Access and Care Engagement Support) can transform cancer care at the cancer center's main and regional sites.

One of the best parts of attending ASCO are the connections and reconnections I make with other advocates and researchers. This year I was able to catch a few of those connections in photos. Great times with  Barbara, Helen, Stacey, Stephanie, Ting Ting, and Annie.  


But there were also the important connections with clinicians and researchers I have worked with through the years on developing trials, the #gyncsm community, ASCO or the NCI and Cancer Hope Network. It was wonderful meeting Drs Markham and Samantha Schrager (Cancer Hope Network),  Cervical Cancer Advocate Linda Ryan and Dr Kohn, as well as Dr Dellinger, Lou, and Dizon.



I also got to reconnect with Dr Ophira Ginsburg at the President's Reception. We first met at the ASCO Annual Meeting in 2015. 

 

This post completes my reporting from #ASCO24. There will be a bit of a break posting on this blog and  from advocacy over the summer but September - Gyn Cancer Awareness month is right around the corner. 

Dee
Every Day is a Blessing! I was blessed to have not only attended but presented at ASCO this year. 

Friday, June 7, 2024

Gyn Cancer Poster Session - Ovarian Cancer posters #ASCO24

Monday was Gyn Cancer Poster day at #ASCO24.  

Here are a few posters along with their study conclusions that I found most interesting this year. 

Tumor-informed ctDNA as an objective marker for postoperative residual disease in epithelial ovarian cancer. #5544
"The present tumor-informed dPCR SV fingerprint ctDNA approach demonstrated feasibility with remarkably high detection rates pre- and postoperatively. Postoperative ctDNA levels differed substantially based on postoperative tumor residuals. These findings suggest that this personalized approach could be used to develop a dPCR SV detection assay and may have clinical utility for postoperative MRD evaluation in patients with primary advanced HGSOC."  
Through the years there has been a lot of talk regarding detecting circulating tumor DNA in the blood of patients. This study showed ctDNA could be used  as a marker in ovarian cancer .


Differences in physical and emotional distress amongst patients undergoing neoadjuvant chemotherapy versus surgery for advanced ovarian cancer: Patient-reported outcomes at diagnosis.   #5546
"Advanced OC patients have high psychosocial needs, with NACT patients reporting severe perceived symptoms on PRO measures. The PSS-10 may be a valuable screening tool for patients undergoing NACT to prioritize supportive care services."

Use of cell-free DNA from ascites to identify variants and tumour evolution in a cohort of patients with advanced ovarian cancer. #5547
This work "demonstrated the reliability of using cfDNA from ascites for molecular profiling, allowing a liquid biopsy of ovarian cancer when tumor tissue access may be restricted. This approach improves accessibility of tumour material, allowing capture of clinically actionable mutations prior to surgery or upon recurrence, following tumour evolution."
There is a difference between cfDNA and ctDNA- "The ctDNA is the fraction of cfDNA that originates from tumor cells, which comes from three sources: apoptosis, necrosis, and active secretion. While ctDNA can come from apoptosis with fragment lengths similar to healthy patients, ctDNA is more fragmented or shorter than cfDNA [20,32,33]. "  Source : NIH

Gemcitabine plus cisplatin in recurrent ovarian, fallopian tube, and primary peritoneal cancer. #5548
"Cisplatin in combination with gemcitabine demonstrates activity regardless of platinum sensitivity status in patients with recurrent ovarian cancer. However, longer platinum-free interval is associated with improved response to this therapy".

 Evaluation of a novel extracellular vesicle (EV) based ovarian cancer (OC) screening test in asymptomatic postmenopausal women. #5553
"The OC Test is capable of highly sensitive and specific detection of HGSC in asymptomatic postmenopausal women one year prior to Dx and can detect HGSC up to three years prior to Dx with superior sensitivity and specificity compared to CA125." 
Finding a screening test for ovarian cancer is important.  This is a different approach looking at extracellular vesicles. " Extracellular vesicles (EVs) are generated and released by cells as part of various physiological and pathological processes, including the progression of ovarian cancer. "Source Science Direct
 

The BEV1L study: Do real-world outcomes associated with the addition of bevacizumab to first-line chemotherapy in patients with ovarian cancer reinforce clinical trial findings? #5563
"This real world study provides support for findings from ICON7 and GOG-0218, suggesting that the benefit of adding bev to first line chemotherapy may be limited to patients with high-risk clinical factors ( Stage IV disease or stage III disease with visible residual disease or no evidence of surgery). "

 
Association of physical activity with self-reported quality of life after primary chemotherapy for ovarian cancer. #5574
"We observed positive associations between health tracker physical activity data and pt-reported QOL. Stronger associations were observed in younger pts. Interventions aimed at increasing physical activity may have broader quality of life benefits for individuals with ovarian cancer." 
When I was first diagnosed I was told to rest during chemotherapy treatment. When I recurred a few years later I was told to try to walk each day. I'm glad that theren is now data saying that exercise has QOL benefits.

 
Artificial intelligence to predict homologous recombination deficiency in ovarian cancer from whole-slide histopathological images. #5578
"By harnessing the power of deep neural networks (DNN), we provide a rapid and scalable solution for HRD prediction, circumventing the limitations of traditional molecular assays. Successful integration of this deep learning model into routine pathology workflows could significantly enhance diagnostic efficiency, reduce the turnaround time and financial cost compared with molecular assay. " 
There were a number of talks at ASCO related to the use of AI. HRD is a marker used to manage ovarian cancer patient treatments.

 
Germline genetic profiles of women with ovarian malignancies: A Myriad Collaborative Research Registry study #5585
"Based on this large registry, our data showed that over 15% of patients with ovarian malignancies have mutations in BRCA (12.5%) or Lynch genes (2.6%) with varying prevalence by race, age, and tumor site. Noted disparities indicate the importance of universal testing in patients with epithelial ovarian malignancies."  
I knew that Lynch syndrome was associated with endometrial cancer but I did not associate ovarian cancer with Lynch sydrome. 

 
Which posters caught your eye? Share them in a comment below.
Tomorrow,  I will post about a equity symposium I attended as well as the  connections and reconnections I made at the annual meeting.
Dee
Every Day is a Blessing!

Thursday, June 6, 2024

Sunday at #ASCO24 Oral Abstracts and Rare Gyn Cancers

My meeting days all started with picking up a bite to eat in the Patient Lounge. The lounge was a great place to meet up with other advocates from around the world, relax is comfy chairs  and pick up a bite to eat at breakfast or lunch. 

Sunday started with the Gyn Cancer Oral Abstract Session followed by an afternoon of meeting with clinicians I am working with as well as learning about Patient Story .

Clear Cell OC

 Recurrent OC no additional benefits from adding Atezolizumab

 Endometrial Cancer 

Pharma support of trials 

When Bad News Comes Through the Portal ... Education Session

Exploring the Uncommon: What's New in Rare Gyn Cancers  - Low grade serous , Melanoma of the gyn tract and neuroendocrine carcinomas of the cervix

Obesity and Endometrial Cancer

Cervical Cancer

Metastatic disease clinical trials 

 Tomorrow I'll review a few of the posters as well as a round-up of the connections I made. 


Dee

Every Day is a Blessing!

Wednesday, June 5, 2024

Saturday at #ASCO24 - Science, Opening Session and My Social Media Panel Presentation

Over the next few days I will share my experience at #ASCO24 , the science I learned , amazing people I spoke to and of course my presentation on social media. 

Late in the day on Friday,  I finally got to McCormick Place. The traffic from the airport was dreadful but I arrived in time to pick up my badge from the Faculty Lounge. Then I headed to my favorite sushi place - Nui Sushi for dinner.

Rapid Oral Abstract Session Highlights. (I missed some sessions as I had scheduled a time to practice my presentation. )

Ovarian Cancer: AXL expression can be used as a biomarker in OC. Those with high AXL expression had improved PFS and OS when treated with Bateraxcept in combo with taxol.

Ovarian Cancer: Use of suvemcitug, an anti-VEGF drug with chemo,  met PFS goal 5.49 months vs placebo at 2.73 months.

Ovarian , Fallopian, Peritoneal Cancers: Oral cyclophosphamide can be used together- Objective response rate 40%

President's Speech and Invited Speakers

Dr Lynn Schuchter,President of ASCO, inspiring speech.  

Jonathan Carlson, Microsoft Health Futures, spoke on AI use in medicine

Abraham Verghese , Stanford spoke next relating to the meeting theme Art and Science

Clinical Science Symposium Novel combinations across the gyn cancer spectrum

Ovarian Cancer combinations:

Cervical Cancer mTOR inhibitors

Ovarian Cancer - overcoming PARP resistance , HRD status did not impact response

A review of combos:

Endometrial cancers CTK4 inhibitors 

Future Endometrial Cancer work

I finished the day participating in a panel with Dr Gil Morgan and Dr Gil Lopez  on Harnessing the Power of Social Media. What an honor! Below are a few tweets from the audience. Dr Morgan spoke on using social media to improve global oncology and the The OncoAlert Consortium. Dr Lopez spoke on using social media to advance research and professional development. I spoke on social media to educate patients with cancer and clinicians.


Check back to read posts highlighting Sunday's Session and the connections I made at ASCO with researchers, clinicians and other advocates. 

Dee

Every Day is a Blessing!